It's not even that. As I've been saying, 6days' question is nonsense on several fronts.
First, the current view among geneticists is that each of us is born with about seven de novo deleterious mutations, not 100. Second, his question assumes that selection must eliminate every single deleterious mutation as soon as it arises. Obviously that's a ridiculous straw man.
But the bigger issue here is that 6days either doesn't understand what the "paradox" is that these geneticists are referring to, or he does understand but is hoping none of the rest of us do. The funny thing is, the
Kondrashov (1995) paper 6days started off citing tells us what the paradox is....right in the title.
Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?
I'm assuming that everyone here understands that a "paradox" is a conflict between two things, where both can't be true. So Kondrashov's paradox is that on one hand his statistical modeling of the evolving human genome shows that we should be accumulating these VSDM's to the point where we should be seeing declines in fitness across the population, but OTOH....
in reality we don't see that.
IOW, the conflict behind the paradox is between the modeling and reality.
So Kondrashov publishes his paper where he basically says "According to my statistical modeling and assumptions, we should be seeing the human population declining in fitness over time, yet, we don't see that. Thus my modeling must be off. Here are some potential factors that may resolve this paradox."
In the ensuing years Kondrashov and other population geneticists continue to work on their modeling and testing it against the data gathered from the real world. And as has been noted, they eventually agree that synergistic epistasis is likely significant factor that explains why the human population isn't declining in fitness as the models suggested.
I don't know if everyone can get full access to
THIS 2017 PAPER, but the authors describe how when they tested synergistic epistasis against reality, they found it to be a real thing.
If you can't get access to that paper,
THIS SITE provides a good summary. "
In other words, there was stronger selection against high mutation counts, as one would predict due to synergistic epistasis."
I know 6days will just wave away all of this because it doesn't fit with his filter, but I hope this post helps you understand the topic better.