Greg Jennings said:
That seems to dispute your claim of 100 new mutations per generation. But let's say your number is absolutely correct. This journal disputes your claim that humans are hopelessly declining.
http://www.ncbi.nlm.nih.gov/pmc/arti...7/#!po=4.74138
I don't think so.
Geneticists since the time of Haldane and Mueller in the 50's have been concerned about the downward trend in fitness, and the increasing amount of genetic problems. Secular geneticists have introduced several models hoping to explain how humans have survived long ages when evidence points otherwise. (hypothesis such as multiplicative, additive, and Mueller neutral mutation random drift, etc) .
A few examples of evolutionists admitting the genetic burden problem.....
H.J.Mueller in 'Human Genetics' (Our load of Mutations). 1950 "it becomes perfectly clear that the present number of children per couple can not be great enough to allow selection to keep pace with a mutation rate of .01..... the present genetic load is a serious one"
in 1986, J.V.Neel in PNAS (The Rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides) " The implications of mutations of this magnitude (30 per generation) for population genetics and evolutionary theory are profound....The question of how our species accommodates such mutation rates is central to evolutionary thought"
In 1995, A.S.Kondrashov in Theor.Biol. ( Contamination of the genome by very slightly deleterious mutations: Whty we have not died 100 times over). In this article he quotes Lande and Lynnch in 1994 saying "VSDMs can rapidly drive the population to extinction" . He says "I interpret the results in terms of the whole genome and show, in agreement with Tachida that VSDMs can cause too high a mutation load"
{Keep in mind..... They are only talking about VSDMs, which are the vast majority of all mutations. Mutations considered deleterious that are fixed in the genome with each generation are likely about 3+ ... added to genetic load)}
In 2002 in Human Mutation, (Direct estimates of human per nucleotide mutation rates at 20 locicausing Mendellian diseases) "The total number of mutations per diploid human genome per generation is about 100...atleast 10% of these are deleterious...analysis of human variability suggests that a normalperson carries thousands of deleterious alleles".
{Keep in mind... This was before the ENCODE results showing function in what evolutionists thought was 'Junk DNA'. If we consider mutations in the non coding regions of our DNA, we may have 300+ mutations added to our genome with each generation)
in 2000, Nachman and Crowell, in Genetics (Estimate of the mutation rate per nucleotide in humans) estimated 175 mutations per generation "The high deleterious mutation rate in humans presents a paradox. ..."
{Reminder...the estimate of 175 mutations is only in the coding region of our DNA. The actual number would be much higher).
In 1999, A.Walker and P.Keightly in Nature ( High genomic deleterious rates in hominoids) "Under conservative assumptions, we estimate that an average of 4.2 amino acid altering mutations per diploid per generation have occurred in the human lineage...
...it is difficult to explain how human populations could have survived..... Deleterious mutation rates appears to be so high in humans and our close relatives that it is doubtful that such a species could survive..."
[ It is easy to explain how humans survived 6,000 years. Evolutionists have difficulty with their long ages]
One more... In 1997, J.F.Crow in PNAS 'The High Spontaneous Mutation Rate' " It seems clear that for the past few centuries harmful mutations have been accumulating...the decrease in viability from mutation accumulation is some 1-2% per generation......I do regard mutation accumulation as a problem. It is something like the population bomb but with a much longer fuse"
